The same way you search, for except in the filters it's kinda flipped: you're entering keywords that must not show up, so
`derpy hooves,spider-man` (whatever the correct spelling is) will block what has both and will show the rest.
If you entered `derpy hooves,-spider-man` you'll block Derpy Hooves if Spider-Man ain't there.
It's 0500am and I haven't tested, but I think that's how it went ...