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Description

From the artist:  
“That’s…  
That’s science! AND ALSO HIGHLY ILLEGAL AND IMMORAL
 
Explanation: Sodium Thiopental is a fast acting Anesthetic, that makes users feel calm, secure, and most importantly, Compliant. Which Twiggles wants.
 
But it needs to get to the brain to take effect. And since Twilight can’t just syringe Applejack with a shot of drugs, she’s trying to sneak it into apples.
 
BUT ALSO stuff you eat doesn’t just go straight to your brain. In fact, there’s a Blood-Brain Barrier preventing exactly that. So to bypass that shit, Twilight is sneaking the drug through via a Peptide Agent which carries the Sodium Thiopental through the membrane.
 
And Then [Science 88/90]: the peptide agent Science Science Magic…
 
EXPLOSION”
 
A sort-of continuation of this.
 
Commission from Pshyzo’s Patreon. Posted with artist’s permission.

safe2164766 artist:pshyzomancer683 sci-twi31202 twilight sparkle356231 equestria girls254608 g42016876 apple21102 beaker242 broken glass349 chemistry428 clothes630222 commission116097 food100683 implied lesbian4713 implied shipping7094 implied twijack65 lab coat2912 lineart24328 messy hair1469 patreon15274 patreon logo9671 phone12343 safety goggles505 scorch marks9 solo1417782 torn clothes6900 wardrobe malfunction6389
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Comments

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limbo

Why not just make an Apple type perfume using the formula and DMSO  
and direct it primarily at the Targets direction (account for wind variables)?
Background Pony #995C
A cute genius in a lab coat performing ethically dubious experiments involving mind-altering compounds to help her get laid? This is like every one of my fetishes in one place.
SkeeterTL
Solar Supporter - Fought against the New Lunar Republic rebellion on the side of the Solar Deity (April Fools 2023).
Non-Fungible Trixie -
Preenhub - We all know what you were up to this evening~
Wallet After Summer Sale -
Happy Derpy! - For Patreon supporters
Magical Inkwell - Wrote MLP fanfiction consisting of at least around 1.5k words, and has a verified link to the platform of their choice
Not a Llama - Happy April Fools Day!

Kingpin Lurker
I see two stories in this.
 
One, Applejack walks in, sees Twi like this, proceeds to help her and finds out just how enamored she is. More or less the, ah, safe version.
 
Two, same deal, but decides to have some… “Fun”. More NSFW and, alas, questionable content. You know what I mean.
 
There’s more, probably, but those are the two that cross my mind.
 
~STL
Ardashir
My Little Pony - 1992 Edition

Thanks for that helpful explanation for all the cavemen like me who wouldn’t have understood the joke otherwise.
 
And Twi better keep this stuff away from Zephyr Breeze or else he’s going to be doping all the women with it.